Mitogen-responsive S6 kinase
نویسندگان
چکیده
منابع مشابه
Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes.
The molecular mechanisms by which overloaded cardiac myocytes increase the cell size (hypertrophy) remain unknown. We have previously shown that mechanical loading increased the protein synthesis and the expression of proto-oncogene c-fos mRNA (Komuro, I., Kaida, T., Shibazaki, Y., Kurabayashi, M., Katoh, Y. Hoh, E., Takaku, F., and Yazaki, Y. (1990) J. Biol. Chem. 265, 3595-3598; Komuro, I., K...
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The binding of growth factors to their cognate receptors at the plasma membrane elicits a variety of biochemical and genomic changes that lead ultimately to cell proliferation or to differentiation. One of the cellular responses is the transcriptional activation of immediate-early genes. While much attention has focused on the identification and characterization of these genes, the mechanisms l...
متن کاملThe mitogen activated S6 kinase; sites of phosphorylation which lead to activation and identification of a putative kinase kinase.
One of the earliest responses of quiescent cells in culture to growth factors and hormones is the stimulation of protein synthesis, which is correlated with increased levels of phosphorylation of cellular proteins [l]. The activation of protein synthesis and cell growth is preceeded by the incorporation of up to 5 mol phosphate into ribosomal protein S 6 . The kinase responsible for modulating ...
متن کاملMolecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.
The molecular structure of a rat hepatoma 70-kDa insulin/mitogen-stimulated S6 protein kinase, obtained by molecular cloning, is compared to that of a rat homolog of the 85-kDa Xenopus S6 protein kinase alpha; both kinases were cloned from H4 hepatoma cDNA libraries. The 70-kDa S6 kinase (calculated molecular mass of 59,186 Da) exhibits a single catalytic domain that is most closely related in ...
متن کاملNovel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling.
Amino acids are required for the activation of the mammalian target of rapamycin complex 1 (mTORC1), which plays a critical role in cell growth, proliferation, and metabolism. The branched-chain amino acid leucine is an essential nutrient that stimulates mTORC1 to promote protein synthesis by activating p70 S6 kinase 1 (S6K1). Here we show that the protein tyrosine phosphatase SHP-2 is required...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1989
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1989.tb14920.x